Fractional-order modeling of myocardium structure effects on atrial fibrillation electrograms

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dc.contributor.affiliationUgarte, J.P., GIMSC, Universidad de San Buenaventura, Medellin, Colombia
dc.contributor.affiliationTobón, C., MATBIOM, Universidad de Medellin, Medellin, Colombia
dc.contributor.authorUgarte J.P
dc.contributor.authorTobón C.
dc.date.accessioned2025-04-28T22:09:39Z
dc.date.available2025-04-28T22:09:39Z
dc.date.issued2024
dc.descriptionAtrial fibrillation (AF) is the most common cardiac arrhythmia with mechanisms of initiation and sustaining that are not fully understood. The clinical procedure for AF contemplates the analysis of the atrial electrograms, whose morphology has been correlated with the underlying structure of the atrial myocardium. This study employs a mathematical model incorporating fractional calculus to simulate cardiac electrical conduction, accounting for tissue structural inhomogeneities using complex-valued orders. Simulations of different wavefront propagation patterns were performed, and virtual electrograms were analyzed using an asymmetry factor. Our results evinced that the shapes of the action potential and the propagating wavefront can be modulated through the fractional order under both healthy and AF conditions. Moreover, the asymmetry factor changes with variations in the fractional order. For a given propagation pattern under AF conditions, variation intervals for the asymmetry factor can be generated by forming sets of simulations with different configurations for the fractional order, representing diverse samples of atrial tissue with varying degrees of structural heterogeneity. This approach successfully reproduces the electrogram negative deflection predominance seen in AF patients, which standard integer-order models cannot predict. Our fractional-order conduction model aligns with the effects of atrial structure on the electrical dynamics observed in clinical AF. Therefore, it offers a valuable tool for studying cardiac electrophysiology, encompassing both electrical and structural interactions of the tissue within a unified model. © 2024 The Authors
dc.identifier.doi10.1016/j.mbs.2024.109331
dc.identifier.instnameinstname:Universidad de Medellínspa
dc.identifier.issn255564
dc.identifier.reponamereponame:Repositorio Institucional Universidad de Medellínspa
dc.identifier.repourlrepourl:https://repository.udem.edu.co/
dc.identifier.urihttp://hdl.handle.net/11407/8840
dc.language.isoeng
dc.publisherElsevier Inc.spa
dc.publisher.facultyFacultad de Ciencias Básicasspa
dc.relation.citationvolume378
dc.relation.isversionofhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85207691987&doi=10.1016%2fj.mbs.2024.109331&partnerID=40&md5=498e30d8641357ed1ead76846d958d8b
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dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.sourceMathematical Biosciences
dc.sourceMath. Biosci.
dc.sourceScopus
dc.subjectCardiac computational models
dc.subjectComplex order derivatives
dc.subjectDiffusion on heterogeneous media
dc.subjectNonlinear systems
dc.subjectDifferentiation (calculus)
dc.subjectElectrocardiograms
dc.subjectLight transmission
dc.subjectMathematical morphology
dc.subjectSolitons
dc.subjectAsymmetry factor
dc.subjectAtrial fibrillation
dc.subjectCardiac computational model
dc.subjectComplex-order derivatives
dc.subjectComputational modelling
dc.subjectDiffusion on heterogeneous medium
dc.subjectElectrograms
dc.subjectFractional order
dc.subjectHeterogeneous media
dc.subjectPropagation pattern
dc.subjectWavefronts
dc.subjectCardiac computational models
dc.subjectComplex order derivatives
dc.subjectDiffusion on heterogeneous media
dc.subjectNonlinear systems
dc.titleFractional-order modeling of myocardium structure effects on atrial fibrillation electrograms
dc.typeArticle
dc.type.localArtículo revisado por paresspa
dc.type.versioninfo:eu-repo/semantics/publishedVersion

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