Lead (Pb++) effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study

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dc.contributor.affiliationTobón, C., MATBIOM, Universidad de Medellín, Medellín, Colombiaspa
dc.contributor.affiliationPachajoa, D., GI2B, Instituto Tecnológico Metropolitano, Medellín, Colombiaspa
dc.contributor.affiliationUgarte, J.P., Grupo de Dinámica Cardiovascular, Universidad Pontificia Bolivariana, Medellín, Colombiaspa
dc.contributor.affiliationSaiz, J., CI2B, Universitat Politècnica de València, Valencia, Spainspa
dc.contributor.authorTobón C.
dc.contributor.authorPachajoa D.
dc.contributor.authorUgarte J.P.
dc.contributor.authorSaiz J.
dc.date.accessioned2017-12-19T19:36:42Z
dc.date.available2017-12-19T19:36:42Z
dc.date.issued2017
dc.description.abstractLead (Pb++) is a toxic agent that can exert adverse effects on the cardiac human health. Pb++ blocks the Ltype Ca++ channels. A decrease in L-type calcium current (ICaL) is an important mechanism favoring atrial fibrillation. It is important to study the electrophysiological Pb++ effects on the atrial action potential in healthy people and those with AF. For this, we study the consequences of Pb++ on action potential, under normal and atrial fibrillation condition using in silico models. Our results suggest that Pb++ blocks ICaL current in a fraction greater as the concentration increases, resulting in an action potential duration shortening, Pb++ has a greater action potential duration effect on control conditions. To our knowledge, this is the first work that has developed mathematical models of Pb++ effect on ICaLcurrent to study its effect on human atrial action potential. © Springer Nature Singapore Pte Ltd. 2017.eng
dc.identifier.doi10.1007/978-981-10-4086-3_17
dc.identifier.instnameinstname:Universidad de Medellínspa
dc.identifier.isbn9789811040856
dc.identifier.issn16800737
dc.identifier.reponamereponame:Repositorio Institucional Universidad de Medellínspa
dc.identifier.urihttp://hdl.handle.net/11407/4263
dc.language.isoeng
dc.publisherSpringer Verlagspa
dc.publisher.facultyFacultad de Ciencias Básicasspa
dc.relation.ispartofIFMBE Proceedingsspa
dc.relation.ispartofIFMBE Proceedings Volume 60, 2017, Pages 66-69spa
dc.relation.isversionofhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85018384836&doi=10.1007%2f978-981-10-4086-3_17&partnerID=40&md5=5ad5b61b412e38f00f9528d881e9d054
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dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.sourceScopusspa
dc.subject.proposalAtrial fibrillationeng
dc.subject.proposalIn silico modelseng
dc.subject.proposalL-type Ca++ currenteng
dc.subject.proposalLead (Pb++)eng
dc.subject.proposalBiomedical engineeringeng
dc.subject.proposalCalciumeng
dc.subject.proposalDiseaseseng
dc.subject.proposalElectrophysiologyeng
dc.subject.proposalAction potential durationseng
dc.subject.proposalAction potentialseng
dc.subject.proposalAdverse effecteng
dc.subject.proposalAtrial fibrillationeng
dc.subject.proposalCalcium currenteng
dc.subject.proposalHealthy peopleeng
dc.subject.proposalIn-silico modelseng
dc.subject.proposalToxic agentseng
dc.subject.proposalLeadeng
dc.titleLead (Pb++) effect on human atrial action potential under normal and atrial fibrillation conditions. In silico studyspa
dc.typeConference Paper
dc.type.driverinfo:eu-repo/semantics/conferenceObject
dc.type.versioninfo:eu-repo/semantics/publishedVersion

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