Atrial proarrhythmic effect of lead as one of the PM10 metal components of air pollution. An in-silico study

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dc.contributor.affiliationPalacio, L.C., MATBIOM, Universidad de Medellín, Medellín, Colombia
dc.contributor.affiliationPachajoa, D.C., GI2B, Instituto Tecnológico Metropolitano, Medellín, Colombia
dc.contributor.affiliationDurango-Giraldo, G., MATYER, Instituto Tecnológico Metropolitano, Medellín, Colombia
dc.contributor.affiliationZapata-Hernandez, C., MATYER, Instituto Tecnológico Metropolitano, Medellín, Colombia
dc.contributor.affiliationUgarte, J.P., GIMSC, Universidad de San Buenaventura, Medellín, Colombia
dc.contributor.affiliationSaiz, J., CI2B, Universitat Politècnica de València, Valencia, Spain
dc.contributor.affiliationBuitrago-Sierra, R., MATYER, Instituto Tecnológico Metropolitano, Medellín, Colombia
dc.contributor.affiliationTobón, C., MATBIOM, Universidad de Medellín, Medellín, Colombia
dc.contributor.authorPalacio L.C
dc.contributor.authorPachajoa D.C
dc.contributor.authorDurango-Giraldo G
dc.contributor.authorZapata-Hernandez C
dc.contributor.authorUgarte J.P
dc.contributor.authorSaiz J
dc.contributor.authorBuitrago-Sierra R
dc.contributor.authorTobón C.
dc.date.accessioned2022-09-14T14:33:29Z
dc.date.available2022-09-14T14:33:29Z
dc.date.issued2021
dc.descriptionParticulate matter (PM) is considered the most severe environmental pollution problem due to its serious effects on human health associated with an increased risk of cardiovascular morbidity and mortality. In this work, a physicochemical characterization of PM10 from the city of Medellin was developed. The results evince that lead (Pb) is one of the most abundant elements since it is present in all analyzed samples. Therefore, Pb was chosen to perform an in-silico study to assess its effects on atrial arrhythmias generation. For this purpose, we developed a model representing the Pb2+ blocking effect on the L-type calcium channel. This formulation was incorporated in a human atrial cell mathematical model and in 2D and 3D models of human atria. The simulations showed a proarrhythmic effect at high Pb2+ concentrations, through shortening of action potential duration inducing the generation of reentrant activity and atrial flutter. The results contribute to the knowledge about the cardiac physiopathological processes, triggered by lead as one of the main PM10 metal components of air pollution, that yields the generation of arrhythmias. © 2021 Palacio et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.eng
dc.identifier.doi10.1371/journal.pone.0258313
dc.identifier.instnameinstname:Universidad de Medellínspa
dc.identifier.issn19326203
dc.identifier.reponamereponame:Repositorio Institucional Universidad de Medellínspa
dc.identifier.repourlrepourl:https://repository.udem.edu.co/
dc.identifier.urihttp://hdl.handle.net/11407/7393
dc.language.isoeng
dc.publisherPublic Library of Sciencespa
dc.publisher.facultyFacultad de Ciencias Básicasspa
dc.publisher.programCiencias Básicasspa
dc.relation.citationissue10 October 2021
dc.relation.citationvolume16
dc.relation.isversionofhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85117947029&doi=10.1371%2fjournal.pone.0258313&partnerID=40&md5=b772c7c8cc2d7908e7d993e1f9d1ea5a
dc.relation.references(2014) UNEP Year Book 2014 emerging issues in our global environment, , United Nations Environment Programme. Nairobi: United Nations Environment Programme
dc.relation.referencesCohen, AJ, Brauer, M, Burnett, R, Anderson, HR, Frostad, J, Estep, K, Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 (2017) Lancet, 389, pp. 1907-1918. , https://doi.org/10.1016/S0140-6736(17)30505-6, PMID: 28408086
dc.relation.referencesBurnett, RT, Cakmak, S, Brook, JR, Krewski, D., The role of particulate size and chemistry in the association between summertime ambient air pollution and hospitalization for cardiorespiratory diseases (1997) Environ Health Perspect, 105, pp. 614-620. , https://doi.org/10.1289/ehp.97105614, PMID: 9288496
dc.relation.references(2017) Applying or Implementing Particulate Matter (PM) Standards, , EPA-United States Environmental Protection Agency
dc.relation.referencesKelly, FJ, Fussell, JC., Air pollution and public health: emerging hazards and improved understanding of risk (2015) Environ Geochem Health, 37, pp. 631-649. , https://doi.org/10.1007/s10653-015-9720-1, PMID: 26040976
dc.relation.references(2018) Ambient (outdoor) air quality and health, , WHO
dc.relation.referencesCosta, DL, Dreher, KL., Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models (1997) Environ Health Perspect, 105, pp. 1053-1060. , https://doi.org/10.1289/ehp.97105s51053, Suppl: PMID: 9400700
dc.relation.referencesJaishankar, M, Tseten, T, Anbalagan, N, Mathew, BB, Beeregowda, KN., Toxicity, mechanism and health effects of some heavy metals (2014) Interdiscip Toxicol, 7, pp. 60-72. , https://doi.org/10.2478/intox-2014-0009, PMID: 26109881
dc.relation.referencesJan, AT, Azam, M, Siddiqui, K, Ali, A, Choi, I, Haq, QMR., Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants (2015) Int J Mol Sci, 16, p. 29592. , https://doi.org/10.3390/ijms161226183, PMID: 26690422
dc.relation.referencesNemmar, A, Holme, JA, Rosas, I, Schwarze, PE, Alfaro-Moreno, E., Recent Advances in Particulate Matter and Nanoparticle Toxicology: A Review of the In Vivo and In Vitro Studies (2013) Biomed Res Int, 2013, pp. 1-22. , https://doi.org/10.1155/2013/279371, PMID: 23865044
dc.relation.referencesCompendium of methods for determination of inorganic compounds in ambient air (1999) Environ Prot Agency, , U.S. Environmental Protection Agency
dc.relation.referencesMasih, A, Saini, R, Singhvi, R, Taneja, A., Concentrations, sources, and exposure profiles of polycyclic aromatic hydrocarbons (PAHs) in particulate matter (PM10) in the north central part of India (2010) Environ Monit Assess, 163, pp. 421-431. , https://doi.org/10.1007/s10661-009-0846-4, PMID: 19319481
dc.relation.referencesMustafi, NN, Raine, RR, James, B., Characterization of Exhaust Particulates from a Dual Fuel Engine by TGA, XPS, and Raman Techniques (2010) Aerosol Sci Technol, 44, pp. 954-963. , https://doi.org/10.1080/02786826.2010.503668
dc.relation.referencesCourtemanche, M, Ramirez, RJ, Nattel, S., Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model (1998) Am J Physiol, 275, pp. H301-H321. , https://doi.org/10.1152/ajpheart.1998.275.1.H301, PMID: 9688927
dc.relation.referencesKneller, J, Zou, R, Vigmond, EJ, Wang, Z, Leon, LJ, Nattel, S., Cholinergic Atrial Fibrillation in a Computer Model of a Two-Dimensional Sheet of Canine Atrial Cells With Realistic Ionic Properties (2002) Circ Res, 90, pp. E73-E87. , https://doi.org/10.1161/01.res.0000019783.88094.ba, PMID: 12016272
dc.relation.referencesBernal, J, Lee, J, Cribbs, LL, Perez-reyes, E., Full Reversal of Pb++ Block of L-Type Ca++ Channels Requires Treatment with Heavy Metal Antidotes (1997) J Pharmacol Exp Ther, 282, pp. 172-180. , PMID: 9223552
dc.relation.referencesTobón, C, Ruiz-Villa, C, Heidenreich, E, Romero, L, Hornero, F, Saiz, J., A Three-Dimensional Human Atrial Model with Fiber Orientation. Electrograms and Arrhythmic Activation Patterns Relationship (2013) PLoS One, 8, p. e50883. , https://doi.org/10.1371/journal.pone.0050883, Kabla AJ, editor. PMID: 23408928
dc.relation.referencesHeidenreich, EA, Ferrero, JM, Doblaré, M, Rodríguez, JF., Adaptive macro finite elements for the numerical solution of monodomain equations in cardiac electrophysiology (2010) Ann Biomed Eng, 38, pp. 2331-2345. , https://doi.org/10.1007/s10439-010-9997-2, PMID: 20238165
dc.relation.referencesJandacka, D, Durcanska, D, Bujdos, M., The contribution of road traffic to particulate matter and metals in air pollution in the vicinity of an urban road (2017) Transp Res Part D Transp Environ, 50, pp. 397-408. , https://doi.org/10.1016/j.trd.2016.11.024
dc.relation.referencesTong, S, Von, Schirnding YE, Prapamontol, T., Tong, S, (2012) Environmental lead exposure—A public health problem of global dimensions, 78, pp. 5-10. , https://doi.org/10.1016/j.isprsjprs.2013.06.001
dc.relation.referencesBluvshtein, N, Mahrer, Y, Sandler, A, Rytwo, G., Evaluating the impact of a limestone quarry on suspended and accumulated dust (2011) Atmos Environ, 45, pp. 1732-1739. , https://doi.org/10.1016/j.atmosenv.2010.12.055
dc.relation.referencesValotto, G, Rampazzo, G, Visin, F, Gonella, F, Cattaruzza, E, Glisenti, A, Environmental and traf fi c-related parameters affecting road dust composition: A multi-technique approach applied to Venice area (2015) Atmos Environ, 122, pp. 596-608. , https://doi.org/10.1016/j.atmosenv.2015.10.006
dc.relation.referencesChien, Y, Lu, M, Chai, M, Boreo, FJ., Characterization of Biodiesel and Biodiesel Particulate Matter by TG, TG—MS, and FTIR (2009) Energy and Fuels, 23, pp. 202-206
dc.relation.referencesSchauer, JJ., Evaluation of elemental carbon as a marker for diesel particulate matter (2003) Expo Anal Environ Epidemiol, 13, pp. 443-453. , https://doi.org/10.1038/sj.jea.7500298, PMID: 14603345
dc.relation.referencesDockery, DW., Epidemiologic evidence of cardiovascular effects of particulate air pollution (2001) Environ Health Perspect, 109, pp. 483-486. , https://doi.org/10.2307/3454657, Suppl
dc.relation.referencesPeters, A, Dockery, DW, Muller, JE, Mittleman, MA., Increased Particulate Air Pollution and the Triggering of Myocardial Infarction (2001) Circulation, 103, pp. 2810-2815. , https://doi.org/10.1161/01.cir.103.23.2810, PMID: 11401937
dc.relation.referencesGlantz, SA., Air Pollution as a Cause of Heart Disease. Time for Action (2002) J Am Coll Cardiol, 39, pp. 943-945. , https://doi.org/10.1016/s0735-1097(02)01709-6, PMID: 11897433
dc.relation.referencesLink, MS, Luttmann-Gibson, H, Schwartz, J, Mittleman, MA, Wessler, B, Gold, DR, Acute Exposure to Air Pollution Triggers Atrial Fibrillation (2013) J Am Coll Cardiol, 62, pp. 816-825. , https://doi.org/10.1016/j.jacc.2013.05.043, PMID: 23770178
dc.relation.referencesMiller, KA, Siscovick, DS, Sheppard, L, Shepherd, K, Sullivan, JH, Anderson, GL, Long-Term Exposure to Air Pollution and Incidence of Cardiovascular Events in Women (2007) N Engl J Med, 356, pp. 447-458. , https://doi.org/10.1056/NEJMoa054409, PMID: 17267905
dc.relation.referencesBrook, RD, Franklin, B, Cascio, W, Hong, Y, Howard, G, Lipsett, M, Air Pollution and Cardiovascular Disease (2004) Circulation, 109, pp. 2655-2671. , https://doi.org/10.1161/01.CIR.0000128587.30041.C8, PMID: 15173049
dc.relation.referencesGordon, T, Nadziejko, C, Schlesinger, R, Chi Chen, L., Pulmonary and cardiovascular effects of acute exposure to concentrated ambient particulate matter in rats (1998) Toxicol Lett, 96 (–97), pp. 285-288. , https://doi.org/10.1016/s0378-4274(98)00084-8, PMID: 9820679
dc.relation.referencesThurston, GD, Ahn, J, Cromar, KR, Shao, Y, Reynolds, HR, Jerrett, M, Ambient particulate matter air pollution exposure and mortality in the NIH-AARP diet and health cohort (2016) Environ Health Perspect, 124, pp. 484-490. , https://doi.org/10.1289/ehp.1509676, PMID: 26370657
dc.relation.referencesWatkinson, WP, Campen, MJ, Nolan, JP, Costa, DL., Cardiovascular and systemic responses to inhaled pollutants in rodents: Effects of Ozone and particulate matter (2001) Environ Health Perspect, 109, pp. 539-546. , https://doi.org/10.1289/ehp.01109s4539, PMID: 11544160
dc.relation.referencesWatkinson, WP, Campen, MJ, Costa, DL., Cardiac arrhythmia induction after exposure to residual oil fly ash particles in a rodent model of pulmonary hypertension (1998) Toxicol Sci, 41, pp. 209-216. , https://doi.org/10.1006/toxs.1997.2406, PMID: 9520357
dc.relation.referencesKim, JB, Kim, C, Choi, E, Park, S, Park, H, Pak, HN, Particulate air pollution induces arrhythmia via oxidative stress and calcium calmodulin kinase II activation (2012) Toxicol Appl Pharmacol, 259, pp. 66-73. , https://doi.org/10.1016/j.taap.2011.12.007, PMID: 22197715
dc.relation.referencesHazari, MS, Haykal-Coates, N, Winsett, DW, Krantz, QT, King, C, Costa, DL, TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmias in hypertensive rats exposed to diesel exhaust (2011) Environ Health Perspect, 119, pp. 951-957. , https://doi.org/10.1289/ehp.1003200, PMID: 21377951
dc.relation.referencesCaldero, L, Carson, J, Koren, HS, Devlin, RB., Canines as sentinel species for assessing chronic exposures to air pollutants: Part 2. Cardiac Pathology (2001) Toxicol Sci, 61, pp. 356-367
dc.relation.referencesCaro, DN, Uribe, LF., (2008) Evaluación de la concentración de metales contenidos en material particulado respirable y su incidencia sobre ambientes intra—extra murales en dos localidades de Bogotá y otras ciudades del país con antecedentes de contaminación atmosférica, , Universidad de la Salle
dc.relation.referencesVásquez, E, Toro, M V, Roldan, JC, González, MI, Jaramillo, ML, Arcos, OF, (2017) Inventario de emisiones atmosféricas del Valle de Aburrá, actualización 2015, , Medellín
dc.relation.referencesMartinez-Angel, JD., Movilidad motorizada, impacto ambiental, alternativas y perspectivas futuras: consideraciones para el Área Metropolitana del Valle de Aburrá (2018) Rev Salud Pública, 20, pp. 126-131
dc.relation.references(2018) Lead poisoning and health, , World Health Organization
dc.relation.referencesWani, AL, Ara, A, Usmani, JA., Lead toxicity: a review (2015) Interdiscip Toxicol, 8, p. 55. , https://doi.org/10.1515/intox-2015-0009, PMID: 27486361
dc.relation.referencesLim, Y-H, Bae, H-J, Yi, S-M, Park, E, Lee, B-E, Hong, Y-C., Vascular and cardiac autonomic function and PM2.5 constituents among the elderly: A longitudinal study (2017) Sci Total Environ, pp. 847-854. , https://doi.org/10.1016/j.scitotenv.2017.07.077, 607, 608, PMID: 28711846
dc.relation.referencesAtchison, WD., Effects of Toxic Environmental Contaminants on Voltage-Gated Calcium Channel Function: From Past to Present (2003) J Bioenerg Biomembr, 35, pp. 507-532. , https://doi.org/10.1023/b:jobb.0000008023.11211.13, PMID: 15000519
dc.relation.referencesPeng, S, Hajela, RK, Atchison, WD., Characteristics of Block by Pb 2+ of Function of Human Neuronal L-, N-, and R-Type Ca 2+ Channels Transiently Expressed in Human Embryonic Kidney 293 Cells (2002) Mol Pharmacol, 62, pp. 1418-1430. , https://doi.org/10.1124/mol.62.6.1418, PMID: 12435810
dc.relation.referencesFerreira de Mattos, G, Costa, C, Savio, F, Alonso, M, Nicolson, GL., Lead poisoning: acute exposure of the heart to lead ions promotes changes in cardiac function and Cav1.2 ion channels (2017) Biophys Rev, 9, pp. 807-825. , https://doi.org/10.1007/s12551-017-0303-5, PMID: 28836190
dc.relation.referencesVassallo, D V., Lebarch, EC, Moreira, CM, Wiggers, GA, Stefanon, I., Lead reduces tension development and the myosin ATPase activity of the rat right ventricular myocardium (2008) Brazilian J Med Biol Res, 41, pp. 789-795. , https://doi.org/10.1590/s0100-879x2008000900008, PMID: 18820769
dc.relation.referencesNattel, S, Dobrev, D., Controversies About Atrial Fibrillation Mechanisms (2017) Circ Res, 120, pp. 1396-1398. , https://doi.org/10.1161/CIRCRESAHA.116.310489, PMID: 28450363
dc.relation.referencesGuillem, MS, Climent, AM, Rodrigo, M, Fernández-Avilé, F, Atienza, F, Berenfeld, O., Presence and stability of rotors in atrial fibrillation: evidence and therapeutic implications (2016) Cardiovasc Res, 109, pp. 480-492. , https://doi.org/10.1093/cvr/cvw011, PMID: 26786157
dc.relation.referencesCosío, FG., Atrial Flutter, Typical and Atypical: A Review (2017) Arrhythmia Electrophysiol Rev, 6, p. 55. , https://doi.org/10.15420/aer.2017.5.2, PMID: 28835836
dc.relation.referencesLeonelli, F, Bagliani, G, Boriani, G, Padeletti, L., Arrhythmias Originating in the Atria (2017) Card Electrophysiol Clin, 9, pp. 383-409. , https://doi.org/10.1016/j.ccep.2017.05.002, PMID: 28838547
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcePLoS ONE
dc.titleAtrial proarrhythmic effect of lead as one of the PM10 metal components of air pollution. An in-silico study
dc.typeArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.localArtículospa
dc.type.versioninfo:eu-repo/semantics/publishedVersion

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